Remnant Lipoproteins and Atherogenesis

Myeloperoxidase, modified lipoproteins, and atherogenesis.

Numerous lines of evidence implicate a role for myeloperoxidase (MPO) in the pathogenesis of atherosclerosis. Enriched within vulnerable plaque, MPO serves as an enzymatic source of eicosanoids and bioactive lipids and generates atherogenic forms of both low- and high-density lipoproteins. These factors likely contribute to clinical studies demonstrating that increased systemic levels of MPO an...

Postprandial Hyperlipidemia and Remnant Lipoproteins

Fasting hypertriglyceridemia is positively associated with the morbidity of coronary heart disease (CHD), and postprandial (non-fasting) hypertriglyceridemia is also correlated with the risk status for CHD, which is related to the increase in chylomicron (CM) remnant lipoproteins produced from the intestine. CM remnant particles, as well as oxidized low density lipoprotein (LDL) or very low den...

Remnant lipoproteins: measurement and clinical significance.

In this issue of the Journal, Chan et al. (1 ) make the significant observation, by three distinct measures, that the concentrations of remnant lipoproteins (RLPs) in plasma are increased in patients with obesity. This increase in RLPs could explain, in part, the increased cardiovascular risk associated with obesity (2 ). To date, although LDLand HDL-cholesterol are clearly accepted as independ...

Plasma high density lipoproteins. Metabolism and relationship to atherogenesis.

Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes

Remnants of lipoproteins, intestinal chylomicrons, and very low density lipoprotein (VLDL), are rapidly cleared from plasma and enter hepatocytes. It has been suggested that remnant lipoproteins are initially captured in the space of Disse by heparan sulfate proteoglycans (HSPGs), and that their subsequent internalization into hepatocytes is mediated by members of the LDL-receptor gene family. ...